IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 26.238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 34.HEDRZPFGACZZDS-MICDWDOJSA-N deuterated chloroform Substances C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 54.150000002894 organic compounds Chemical class 0.000 abstract description 3.239000005456 alcohol based solvent Substances 0.000 claims description 2.RHQDFWAXVIIEBN-UHFFFAOYSA-N 2,2,2-trifluoroethyl alcohol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 claims description 5.125000006239 protecting group Chemical group 0.000 claims description 7.239000002904 solvent Substances 0.000 claims description 9.BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims description 43.150000001875 compounds Chemical class 0.000 claims description 59.125000004433 nitrogen atoms Chemical group N* 0.000 claims abstract description 5.-1 t-butoxycarbonyl Chemical group 0.000 claims abstract description 20.238000010438 heat treatment Methods 0.000 claims abstract description 24.150000001298 alcohols Chemical class 0.000 claims abstract description 32.238000010511 deprotection reaction Methods 0.000 title description 10.Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from US1393107P external-priority Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG Publication of EP2070899A1 publication Critical patent/EP2070899A1/en Status Withdrawn legal-status Critical Current Links Original Assignee F Hoffmann La Roche AG Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Wagner Current Assignee (The listed assignees may be inaccurate. Inventor Jason Chi-Chung Choy Saul Jaime-Figueroa Joseph M. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Withdrawn Application number EP08170637A Other languages German ( de) Google Patents Deprotection of N-BOC compoundsÄownload PDF Info Publication number EP2070899A1 EP2070899A1 EP08170637A EP08170637A EP2070899A1 EP 2070899 A1 EP2070899 A1 EP 2070899A1 EP 08170637 A EP08170637 A EP 08170637A EP 08170637 A EP08170637 A EP 08170637A EP 2070899 A1 EP2070899 A1 EP 2070899A1 Authority EP European Patent Office Prior art keywords boc compound nmr cdcl fluorinated alcohol Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents EP2070899A1 - Deprotection of N-BOC compounds EP2070899A1 - Deprotection of N-BOC compounds
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